Depto. Química Orgánica

REACTIVITY OF ANHYDRIDES

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15/07/2017
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Anhydrides are close in reactivity to acyl halides as explained as well by the negligible contribution of the resonance form with the positive charge on the L (carboxylate) group.
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The mechanism is the usual addition-elimination process.Image
The versatility of the anhydride function is not as wide as that of acyl chlorides.
Please, notice that a carboxylate instead of chloride is always obtained as by-product.
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