Depto. Química Orgánica

THE THIRD SEAr

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15/07/2017
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The attachment of three groups to a benzene by consecutive SEAr reactions is not easy a task at all.
One must start by the least deactivating groups because, if not, the last reaction would become impossible.
How do you explain this result?
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Piece of cake! The two groups direct to the very same position.
What about this one?
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If two substituents conflict with their directing trends, the activator or the weaker deactivator beats the other.
How come this nagative result?
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If the benzene has two deactivators in the first place, the third SEAr can be even impossible to perform.
Last but not least, how can one explain this result?
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If two groups are already in meta position to each other, the third substitution won't go to the position in between them due to heavy steric congestion.