Depto. Química Orgánica

PREPARATION OF AMINES BY REDUCTION

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15/07/2017
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There are nitrogen functions in a high oxidation state that can de reduced to give amines.
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Reduction means the grabbing of electrons from another species that sumultaneously oxidizes.

Metals are excellent for this purpose.
The substitution of a good leaving group by cyanide leads to nitriles whose reduction yields amines - with one more carbon!!!
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Amides ('with D') render amines ('with N') by reduction:
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Ammonia and amines are nucleophiles that could attack aldehydes or ketones.
If one introduces a reducing agent in the reaction medium, the intermediate imine is reduced in situ leading overall to a new amine.
Video: Aminación reductora
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