Problems and exercisesAcid-Base Properties
1. The least basic
Why is the carbonyl of an acid chloride the least basic among the derivatives (pKa of the conjugate acid ≈ −9)?
2. α-Hydrogens
Why are the α-hydrogens of acetyl chloride (pKa ≈ 16) more acidic than those of methyl acetate (≈ 25)?