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Problems and exercisesLidocaine

Exercise 1

Chloroacetyl chloride is used in the first step of the synthesis of lidocaine. Why does the aniline react with the acyl chloride and not with the CH2Cl? What is the sodium acetate for?

Exercise 2

Procaine is 2-(diethylamino)ethyl 4-aminobenzoate. Propose its retrosynthesis and synthesis, and explain why its duration of action is shorter than that of lidocaine.

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