Problems and exercisesProtection of functional groups
Exercise 1
Methylmagnesium bromide is to be added to the ketone of methyl 4-acetylbenzoate without touching the ester. Is protection needed? Propose a sequence.
Exercise 2
A molecule carries a primary alcohol protected as a TBS ether and a secondary one as a benzyl ether. Say how to release each without touching the other and which reagents would destroy both protections.