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qorganica.es qorganica.comAdvanced Organic Chemistry Course map Español

Problems and exercisesMichael (conjugate) addition

Exercise 1

Write the product of the Michael addition of ethyl acetoacetate to acrylonitrile with a catalytic amount of sodium ethoxide, and explain why a catalytic amount of base is enough.

Exercise 2

Propose a synthesis of hexane-2,5-dione from acetone and a nitroalkene.

Exercise 3

Why do organocuprates give conjugate addition to enones while organolithiums attack the carbonyl?

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