Problems and exercisesChiral auxiliaries
Exercise 1
Which cleavage conditions of the Evans auxiliary would you use to convert the aldol in the scheme into (a) the acid, (b) the methyl ester and (c) the 1,3-diol? Why is LiOOH, rather than LiOH alone, used to obtain the acid?
Exercise 2
If the enantiomeric oxazolidinone, (R)-4-benzyl, is used in the reaction of the scheme, which product is obtained?